Nathan was born in Pittsburgh, PA and moved to the Philly area in 2002 to attend Haverford College, where he studied molecular biology and Spanish literature. After spending two years doing lab research, he started at Penn for medical school and graduate school. Nathan stayed on for his residency in internal medicine, as well as his subspecialty training in oncology. He is now in the final years of his fellowship specializing in treating patients with leukemia, and spends most of his time in a lab developing new ways to use the immune system to fight cancer. In the wake of the 2016 election, he started a group called Moving Philly Forward, focused on helping to educate people about the structure of Philadelphia government and supporting candidates for local office. His wife is also an oncologist, although treats children, and they have a 16 month old son named Max.